The “reprogramming” hypothesis implies that a normal immune system can’t cope with extremely low chronic levels of HCV. I’ve seen no evidence to support such a view.
Thanks for the answer.
This is not intended to be combative - but want to point out that I suspect neither have you seen any evidence supporting the other view.
The way in which HCV interacts with the immune system is complex - as you'd expect of a chronic infection (indicating some way of avoiding the immune system). If(!) what keeps the immune system from clearing hcv is genetic mutation of hcv then it seems quite plausible that relapse can occur even from low levels.
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