I don't believe anyone would say there won't be a case of PML somewhere. However - the label, which puts the potential at 1:1000 is high. If it were accurate, there would be about 30 cases of PML by now instead of zero.
The Plex study has shown that there's a fairly rapid way to clear Ty from the body if necessary, and I hope that will allow more neuros to begin prescribing it as 1st line therapy.
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