"they have shown no willingness to reduce their burn"
As I recall, this was one area that Cox said at the ASM that they plan to address going forward, namely reducing their burn, but maybe others that were present at the ASM will have a better recollection of what he said exactly in that regard...
"This upcoming PIPE, when accompanied by the coming reverse split, will be a 1-2 punch that will hit the stock price even more (I know that is hard to believe)."
All of those issues are already more than priced into the stock price. Additionally, while I think a financing in the coming months is quite probable, I do not think it will be as "significant" as you hint it will be nor is it a certainty because new partnership deals may be forthcoming. It is not totally out of the realm of possibilities that, with some luck, GTCB could turn profitable in 2009 when you consider the possible new partnerships, the revenues from ATryn EU especially if they expand the labeling to pregnancies, and the possible US ATryn approval and launch...