>I think there is a good (50/50+) chance we see Roche initiate a study of some sort with a protease and polymerase late this year<
I agree. Roche is probably trying to decide whether to start with R1626 or R7128. They would naturally prefer the former but they will probably pick the latter.
Do you think if telapravir is approved 191 will have to go head to head vs them? Could add a lot of time, cost and risk to pivotal studies. Also would it have to be non inferior or superior?