[Updated for SEC filings through 2/17/09. Samana Capital is the only new 13G filer. Officer/director holdings shown below are as of today and include all options, whether or not they are currently exercisable. Institutional holdings shown below are as reported on Form 13G and are accurate as of 12/31/08.]
Shares Stake Novartis 4,708,679 11.8% Visium Asset Mgmt 3,349,122 8.4% T Rowe Price 3,338,081 8.4% Federated Investors 2,824,546 7.1% Samana Capital 2,109,760 5.3% Palo Alto Investors 1,183,658 2.9% Robert Langer* 1,046,022 2.6% Craig Wheeler† 825,000 2.1% Alan Crane‡ (Polaris) 652,602 1.6% G. Venkataraman** 601,812 1.5%
*Director and co-founder. †Director and CEO. ‡Director and former CEO. **CSO.
Atlas Venture Fund, which was a 6.7% holder as of 4/1/08, distributed its shares to the limited partners and no longer holds shares in its own name.