Worse yet, this is done on an excel spreadsheet. I guess my simulation would have to wait till I have figured out those wash sale cost basis (before this I actually thought that Real Analysis was the most difficult subject). There are some nice features in East 5.0 though- you could pretty much plug in as many exponential pieces as possible, and it will simulate trial success under all kinds of group sequential boundaries in a matter of seconds. Pricy software - 12K for a single license - but surely peanut money and well worth the spend for Dendreon.