Re blood factor modification to extend circulating half-life I commend to your attention this patent application:
[0022] Some of the chief advantages of the present invention include novel high molecular weight heterobifunctional polymeric conjugates capable of enhancing the circulating half-life... [0097] Proteins, polypeptides and peptides of interest include, but are not limited to, hemoglobin, serum proteins such as blood factors including Factors VII, VIII, and IX... [0101] The proteins or portions thereof can be prepared or isolated by using techniques known to those of ordinary skill in the art such as tissue culture, extraction from animal sources, or by recombinant DNA methodologies. Transgenic sources of the proteins, polypeptides, amino acid sequences and the like are also contemplated. Such materials are obtained from transgenic animals, i.e., mice, pigs, cows, etc., wherein the proteins are expressed in milk, blood or tissues...
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