by regulating chemical reactions (ligand:target binding) of other receptors, on the two dimensional endothelial membrane, I think ATryn could have an effect on many pathways that send a signal from blood plasma to cytoplasm.
While my understanding on this topic is limited at present, I'd imagine that the difficulties with ATIII of IV dosing and non-specific activity for most non-emergent/hospital-based needs for anti-inflammatories would be limitations, but if our goat-produced alpha feto-protein fails in its trials for RA/uveitis, we can throw them ATIII!
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