>VRTX HGSI –will the FDA approve telaprevir (i) only in combination with pegylated interferon and ribavirin or (ii) in combination with any approved IFN-alpha and ribavirin?<
The latter, IMO.
The Avastin label in metastatic colorectal cancer, which includes use with all varieties of infusional-5FU chemotherapy, is a good precedent.