Replies to post #8461 on GTC Biotherapeutics (fka GTCB)

[DewDiligence]

A key distinction between hirudin and AT is that the former inhibits only thrombin while the latter inhibits several factors in the coagulation cascade.

[DewDiligence]

>Antithrombin III - 432 amino acids
hirudin - 65 amino acids<

I prefer to think in terms of kDa rather than AA’s. Here are the sizes of selected molecules in kDa:

Thrombomodulin (ART-123) 74
AT (ATryn) 58
aPC (Xigris) 55
Hirudin 7