Replies to post #8456 on GTC Biotherapeutics (fka GTCB)

[MTB]

A quick back and forth with the authors on why hirudin might prove to be more effective than ATIII in sepsis:

"Hirudin is a small peptide inhibitor and more likely to equilibrate with the extrvascular space as compared to the protein inhibitor antithrombin.

Wolfram Ruf"

This of course, is opinion, without a lot of clinical data either way.

While other thrombin inhibitors (hirudin or others) might ultimately prove to be more effective, these data are much more suggestive than not that ATIII should be expected to have good effect in sepsis.

Best,
MTB

[jessellivermore]

MTB very nice post''''''

Do you think increased vascular permeability in face of the inflamation might help the AT3 get to the scene of the crime... Also I wonder how many of those other studies involved concommonent use of heparin.

[jessellivermore]

One more thought;;;;;;; actually two...

If the lymphatics are dischargeing dendridic cells and cytochymes into the thorcic duct and subsequently in to the S.Venae Cava and into the lungs.....does this mean thoracic duct canulization and drainage should be done in DIC. Secondly the authors are saying the the dendridic cells do enter the blood stream ...the central veins,,Right heart and lungs and should run into AT3 there.