Von Willebrand's is an interesting condition. Unlike the hereditary coagulopathies such as Hemophilia or Christmas disease VW is not transmitted on the X chromosome as a recessive and seen mainly in males. Von W is transmitted as an autosomal dominant although 25% of cases are thought to occur via spontaineous mutation without previous family history. Thus unlike the hereditary coagulopathies Von Willebrands is equally seen in men and women. It comes in three different varieties and has generally only a minimal effect on coagulatin. VW mainly effects platelet adhesion: platelet clumping is an early event in "primary hemostasis" which is used to stop the bleeding. Coagulation is "secondary hemostasis" which adds stability and permanentcy to the process. VW can vary enourmously in severity from case to case and can be periodic and episodic. Even though the coagulation is almost normal in VW, Factor VIII surprisingly will correct the platelet abnormality in most cases.
Market Data 
Markets 
AI
