"I don’t use options because I rarely have a strong feeling about when a stock will move"
Dew,
That's why I am looking into leaps - Jan. 2006 seems like plenty of time for the market to come to its senses (although Jan 2005 is tempting too). Anyway, you must have some gut feeling that the DNA correction is coming soon, or you wouldn't be shorting now. Don't you have to pay margin loan interest for the duration of your short?
What kind of valuation metrics would you use for DNA. PE?, PEG?, market cap to revenues? And what companies would you compare it with? Amgen? Just wondering where your $80 target came from.