Replies to post #5464 on GTC Biotherapeutics (fka GTCB)

[dewophile]

the "finer points" might affect branching, types of sugar moieties added, pH, etc., but at the end of the day are post-translational events that are not easy to modify. inserting a glycosylation signal sequence in the protein backbone is trivial, and at the end of the day probably far more powerful in altering pK characteristics