Re: Acuity’s siRNA drug for AMD:
Acuity’s data are quite impressive, but there is a major caveat here: AMD in the animal models used for preclinical testing is an artificial form of the disease induced by a laser. Thus, there is a distinct possibility that these animal models do not capture all of the essential features of “real” AMD, which is caused by pathology associated with aging.
Still, Acuity’s preclinical data appear strong enough that I think their drug could be a legitimate threat to the other AMD candidates which are given by intravitreal injection. Definitely one to keep on the radar screen.
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