Replies to post #4620 on GTC Biotherapeutics (fka GTCB)

[poorgradstudent]

The enzymes that digest DNA in the stomach are the same as the ones in the blood.

[DewDiligence]

>I was merely pointing out that our body has defense mechanisms against "eating steak" because of our digestive track while it does not have such defense mechanisms against direct transfusions into the blood.<

If goat antigen in the bloodstream of ATryn users were of practical consequence, antibodies to ATryn would be observed. Yet there have been none. From the 2Q07 CC:

>>
Our plan remains to file our BLA with the FDA by the end of Q1 2008. Our results package will also include the 90 day antibody data required under the protocol following the treatment of the last patient. Similar data was required by the EMEA and no antibodies were observed.
<<

No antibodies to ATryn have been observed in any of the several hundred subjects who have received ATryn during the past decade.