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gfp927z

08/02/07 6:05 PM

#7895 RE: haysaw #7892

Haysaw, That would be my guess - that the conf call is primarily to coincide with the filing of the IND with Psychiatric, and also to fill us in on what Neurology had to say after completing their evaluation of the tox data. The conf call should help clear up some of the remaining uncertainties out there over dosing levels/durations, Neurology's overall stance on the histo/artifact issue, etc. Then we'll have approx 30 days to wait for Psychiatric's decision on the ADHD IND.

Fwiw, I did lighten up today, continuing my ongoing tradition of timing (and mistiming) this stock. The warrant share overhang factor is something I just don't have a good handle on, so I figure I'll let it settle out and then reevaluate the situation / stay flexible, etc. I still think we're likely to get good news from Neurology or they wouldn't have liberalized the dose at all. There are always question marks out there until we get the final verdict from Psychiatric, but the conf call should help clarify where we stand.








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neuroinv

08/02/07 8:10 PM

#7909 RE: haysaw #7892

I think the event that will trigger the CC is filing the IND. The content will also include an update on Neurology's completion of their review of CX717; progress with other low-impacts like CX701, and the status of the high-impact program. The kind of information that Cortex shareholders used to demand, and complain when it wasn't forthcoming. There might be a 5% chance of a partnership, a 20% chance of an inlicensing. I see little likelihood that there will be a PIPE announced, as I stated earlier, the timing would be virtually indefensible.

It's interesting to me that, having posted a comparison with Targacept's even more precipitous drop, there was, so far as I can tell, zero response on this Board to that comparison. I could mention Neurogen, whose share price has plummeted in spectacular fashion without any clear precipitant. In neither of those cases, has there been any reason to expect a PIPE...there has been an exit for reasons that strike me as sectoral profit-taking, not due to individual company dynamics (other than the fact that there was a profit to be taken). The difference for Cortex is the warrant conversion, where a sectoral retreat becomes temporarily amplified by conversions and sales. But that also will provide cash, making a PIPE even more unlikely.

Cortex shareholders and observers can, if they choose, continue to torture themselves with a search for some hidden agenda, some secret that we will be the last to know. Occam's razor--the law of parsimony--suggests that adding extraneous explanatory hypotheses does not improve the accuracy of the guesswork. And most of the conjectures offered of late smack of the extraneous, IMHO.

NeuroInvestment