>How did Novartis get into the lucentis program? Why didn't Roche handle the eu markets?<
NVS has a longstanding presence in ophthalmology (dating back to the Ciba-Geigy days), while Roche has never been a player of consequence in the field.
Roche had the first option on Lucentis outside the U.S., as they do with every drug from DNA, but they wisely declined.