Replies to post #4036 on GTC Biotherapeutics (fka GTCB)

[DewDiligence]

Auxiliary Reference List of Antithrombin Papers

[This list includes entries deemed to be of secondary importance for ATryn use in DIC/sepsis as well as entries relevant to other potential indications for ATryn. (A separate post accessible from the ReadMeFirst primer contains the primary scientific support for the use of ATryn in DIC/sepsis, including discussions of the KyberSept study.) Items within each heading are in reverse chronological order.]


Edits: Added abstract on preclinical study in DIC.


DIC / Sepsis (see note above)
#msg-23829730
#msg-14277430 Thrombomodulin in DIC
#msg-13512229 Meta-analysis
#msg-13150691
#msg-13102302
#msg-12975208
#msg-12960346
#msg-12743571
#msg-12681781
#msg-12100172
#msg-11211288
#msg-10232620
#msg-9363231
#msg-8452794
#msg-7268415


Chemistry and Pharmacokinetics
#msg-13173404 Covalent linkage between AT and heparin
#msg-11801772 PK of ATryn vs plasma AT
#msg-7669971 AT glycosylation
#msg-6995560 AT glycosylation


DVT During Pregnancy
#msg-9327646
#msg-8988372
#msg-8256536
#msg-7834418
#msg-7050226


Cancer
#msg-18991235 Pediatric ALL
#msg-12476761 Coagulation in cancer
#msg-12181584 Acute lymphoblastic leukemia
#msg-11804544 Use of anti-thrombotics in cancer
#msg-9460320 Liver mets in colon cancer
AT fragment in lung-cancer model


Miscellaneous
#msg-20210837 ARDS
#msg-15039853 Burns
#msg-14277297 Polymicrobial peritonitis
#msg-14199820 Platelet adhesion
#msg-13345041 Thrombin increases cardiomyocyte death
#msg-13292817 Pediatric ECMO
#msg-12714409 Retinal vein occlusion
#msg-11611213 VOD combo treatment with defibrotide
#msg-11609770 SPK transplantation
#msg-10969504 Recurrent thromboembolism risk
#msg-10321740 Aneurysm surgery
#msg-7528643 Overview of hereditary deficiency