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DewDiligence

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DewDiligence

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Re: None

Sunday, 08/28/2005 3:09:16 PM

Sunday, August 28, 2005 3:09:16 PM

Post# of 257257
Abstract:
Inherited thrombophilia: an update

[If anyone has access to the full article, please post.]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_...

>>
Clin Lab. 2005;51(7-8):357-65.

Franchini M, Veneri D.

Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona, Verona, Italy

Inherited thrombophilia can be defined as a genetically determined predisposition to develop thromboembolic complications. Inherited prothrombotic risk factors include antithrombin deficiency, protein C and protein S deficiencies, activated protein C resistance due to factor V Leiden mutation, inherited hyperhomocysteinemia, prothrombin G20210A variant, dys- and hyperfibrinogenemia and elevated factor VIII levels.

In this review we briefly analyze, from an epidemiologic, laboratory and clinical point of view, the main inherited prothrombotic risk factors. Finally, we discuss the synergism between genetic and acquired prothrombotic risk factors in some conditions such as pregnancy and cardiovascular diseases.

PMID: 16122145 [PubMed - in process]
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