Quiz: Why hasn’t ZGEN (or anyone else) combined recombinant thrombin with fibrinogen in order to make a fibrin tissue sealant?
Right now the only Fibrinogen available is derived from human plasma. Expression of functional fibrinogen in bacterial or yeast expression systems has not been feasible because of the complexity of this multi-chain protein. Expression is mammalian cell culture cells has been demonstrated, but is unsuitable and too expensive to produce the large amounts of fibrinogen needed.
As a consequence Fibrinogen is available in very limited quantities and extremely expensive. Far too expensive to use it in fibrin tissue sealant on a wider scale.
This may all change, once Pharming can bring its recombinant human Fibrinogen to market. As far as I know rhFibrinogen is officially still in pre-clinical development. However, Pharming has been testing its product in tissue sealants with the US Army.
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