There is also Prialt, non-opioid, certainly a niche drug, and a difficult one to dial in the correct dosage plus it is an intrathecal therapy. However, I have 2 acquaintances who, after 15+ years of intractable pain as a result of a severe auto accident, have finally found relief. It took 6 months to taper off the opiates which dulled the pain some, but not nearly enough. They now live a relatively normal, mostly pain free life.
I believe this was a first in class drug, so hopefully there are others with improbements coming along.
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