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Replies to #48340 on Biotech Values
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Pre_Clinical

06/08/07 8:23 PM

#48341 RE: jellybean #48340

I too wonder about the bioavailability of these crystals. That's why I like pancreatic insufficiency route vs. growth hormone for this technology platform. The pills containing the digestive enzyme crystals could be slowly dissolved upon ingestion. Also, there's no reason why crystals could not still retain enzyme activity in their lattice form in the stomach. hGH on other hand, cant bind to its receptor in the crystalline form and you obviously dont want protein crystals circulating in your bloodstream. How exactly the hGH in the crystal is dissolved into a bioavailable monomeric form is critical here.