Replies to post #3745 on GTC Biotherapeutics (fka GTCB)

[floblu14]

Although GTC hasn't had any patent applications of late, I would like to repeat their last regarding ADCC. Seems they're on tract to score big on this one -

>Abstract of WO2007048077 April 26, 07

The invention relates, in part, to antibodies with increased ADCC activity. Methods of producing such antibodies are also provided. The antibodies of the invention are produced in mammary epithelial cells, such as those in a non-human transgenic animal engineered to express and secrete the antibody in its milk. The antibodies or compositions comprising the antibodies can be used to treat disease in which ADCC activity provides a benefit. In one embodiment, therefore, the antibodies or compositions comprising the antibodies can be used to treat cancer, lymphoproliferative disease or autoimmune disease.<

http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2007048077&F=0

http://v3.espacenet.com/origdoc?DB=EPODOC&IDX=WO2007048077&F=0&QPN=WO2007048077

[dewophile]

adcc - medx
I don't follow the board closely so this has probably been mentioned, but medx has a non-fucosylated follow on drug candidate
I'm curious as to their non-fucosylated platform if anyoen has any insight (tia)