They were both 'missed' by the assumptions of the genome project, and are quite often 'invisible' to SNP analysis methods.
Do you need to learn how the genome project was accomplished?
Do you understand the process they employed?
Do you realize that such a process will not uncover multiple serial copies of large DNA segments? Can you see the significance?
Do you understand how SNPs are detected?
Do you realize that a polymorphism in one segment of a CNV will trigger a positive response on a SNP array, EVEN if the SNP does not occur in the other copies? Can you see the significance?
DO you realize that with current SNP/AIM assays, there is no way to determine whether someone has one copy of a DNA segment or ten copies? The SNP results would be the same for either case. Can you see the significance?
Go back and read the articles, especially the parts that explain how multiple copies of a single gene provide variable susceptibility to HIV but are 'invisible' to SNP analysis.
Then get back to us, would you?
regards,
frog
Market Data 
Markets 
AI
