The larger bid-ask spread and general illiquidity of the option contract are factors inherent to option trading which simply offset the leverage advantage --- it's simply part of the risk/reward anaylsis which should preceed the trade --
IMTO if you can't justify the option trade based upon the current momentum, volatility, etc etc you shouldn't be trading the stock anyhow unless you are as good as our leader Zeev
I recall you mentioning it some time ago and I could hit myself for not jumping in.. I just looked at the chart today and couldnt believe the runup.. now THATS a return.. Forget CRXL : )