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Replies to #43009 on Biotech Values
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Lungman424

03/12/07 8:08 PM

#43010 RE: DewDiligence #43009

Can lengthening telomeres make a good cosmetic?
I rather doubt it, but here’s a company who wants
you to think it can.

Beauty along with a lot of other things is in the eye of the beholder..Eating Garlic tablets have been proven over and over again to be absolutely worthless, but someones sure is making a buck selling it.. Hell if Suzanne Sommers can make millions selling useless thigh masters I'm sure someone can make a buck selling the lastest miricle anti aging cow manure...Never underestimate the ability of huge amounts of people willing to blow money on worthless products...now of I could only figure out how to make this Clapper sign on-sigh off my computer.
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microcapfun

03/13/07 1:40 AM

#43022 RE: DewDiligence #43009

>>Can lengthening telomeres make a good cosmetic?
I rather doubt it, but here’s a company who wants
you to think it can.<<

My first reaction to seeing the Geron PR this morning was to let out a "have they sunk so low as to deal in cosmetics and nutraceuticals?" moan. My 2nd reaction was to think that it could be more serious than that.

When telomerase is activated in completely normal somatic cells, you don't get cancer and the cell goes through more population doublings before reaching senescence. BUT ... consider a cell which has been around the block a few times, has p53 disabled, Ras/Raf/Mek/Erk etc. on hyperdrive ... and is only missing the activation of telomerase to become a tumor cell - hell ... a tumor STEM cell. Maybe this cell has senesced and is quietly minding its own business ... And suddenly is has telomerase temporarily activated and gets to roll the dice a few more times to see if it can activate telomerase permanently.

Come on ... snake eyes!

In small animals, telomerase activation has given rise to an increased number of cancers in some experiments.

So one might worry quite a lot about a telomerase activating nutritional supplement on the market (mixed in with ginko biloba, warts from St. John, etc.) that has never been tested in humans.

On the other hand, the Geron CEO has claimed that in early experiments, their particular small molecule telomerase activator has activity only in cells which are not "pre-malignant".

I have no idea what mechanism could give rise to that. Is it possible?

I suspect that Geron's deal is arranged so that if Asia Biotech Corp's nutraceutical gives a lot of people cancer, Geron will be indemnified or otherwise off the legal hook.

Now if it doesn't give anyone cancer, I'll probably be interested in taking it! Experiments have shown, in particular, that T cells are more potent if they have longer telomeres ...

micro
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jessellivermore

03/13/07 8:03 PM

#43045 RE: DewDiligence #43009

Perhaps everyone knows this ,,,,,,,,,,,,,,

As a relatively infrequent vistor to this board it seems alot of the posts involve cancer treatment and I gather everyone knows cancer cells contain a telemerase which restores the telemeres after division conferring immortality.

From an aging point human cells can be divided into three types, those who virtually never divide eg. nerve cells, those who appear to have unlimited ability to divide,eg epidermal cells, and those with a limited number of cell divisions, mesenchymal eg, fibroblasts, muscle, fat. In this last group the number of divisions is determined by telemere length. Of the three cell types some current theories of aging feel it is mainly a problem in the last group. The telemeres representing a biological clock. IMHO there is little question that changes in number of connective tissue cells are responsible for most of the visual changes seen in aging appearence. I am a plastic surgeon.

I first became aware of Geron sometime in the nineties. I am not currently a shareholder. My intro was via Dr Judah Folkman
of Boston Childrens etc. Dr Folkman has always been considered one of HMS's brightest. I believe he was working with GERN on his tumor angiogenisis at the time. If you are focused on cancer I can see how you might look on telemerases as bad things. However they could contain the key to retaining youth. Understood there is much more we don't know about aging than we do.

If you ask almost anyone you meet,," can aging be halted"? They will tell you "No it is impossible". But remember a hundred and a few years ago if you ask anyone "Can a flying machine be built"?, They also would have told you, "no it is impossible."

We can not at this time say it is impossible to halt aging. We can only say no one has been able to do it so far.