Sword only depletes high 4-1bb+ cells, Dr. V mentioned that in presentation. You can check the poster on 836 to see this There is not many activated effectors in MSS CRC anyway unlike NSCLC. CD58 KO also raise the threshold for sword to deplete most immune cells activated.
selective depletion of pathogenic immune cell subtypes in RA and SLE disease samples, including over 99% of B cells, plasmablasts, and plasma cells and more than 90% of activated CD4+ and CD8+ T cells, while sparing non-activated T cells
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