I found an interview yesterday in which two of the authors laid out a three-pillar engineering roadmap to turn INSTALL from a proof-of-concept into something clinically usable.
A primary focus will be identifying LNP formulations capable of efficiently co-delivering recombinase mRNA and INSTALL. Concurrently, refining the chemical modifications and sequence composition of the PIP oligo. Furthermore, continued engineering of recombinases. With multiplicative gains across all three areas that should bring efficiency into clinically relevant territory.
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