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01/09/26 12:02 AM

#908 RE: NY1972 #905

4-1BB is an activation marker and is not Treg-specific. So the ADR could engage all 4-1BB+ activated lymphocytes, including some Tregs (not all cancers will have Tregs that are 4-1BB+).

To selectively deplete Tregs, you would need additional specificity (e.g., CCR8) https://onlinelibrary.wiley.com/doi/10.1111/imm.13337

A number of mAbs (some CCR8-targeting) are in development https://ascopubs.org/doi/10.1200/JCO.2025.43.16_suppl.3076 https://www.asco.org/abstracts-presentations/233962