Replies to post #686 on SeaStar Medical Holding Corp (ICU)

[Whalatane]

Hawthorne Effect more likely in Statin trials ...or your favorite ..the Reduce It trial :--)
These patients are in the ICU , most with sepsis and all with at least one critical organ crashing . They may not even aware they are in the trial ...that decision being made by next of kin and their MD.

So the last data from the Pediatric SAVE registry

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These new data are on track to validate or potentially exceed a 50% reduction in loss of life compared to historical data, as reported in Kidney Medicine.

If the interim review is seeing a 50% ( even 40% ) relative risk reduction in mortality for those on ICU's SCD filter ..vs standard of care ...theres a strong case for limiting further enrollment say past 160 patients .
A 40% relative risk and an absolute risk reduction of 20% is probably not enough to cross a strict stopping boundary of p<.01...but definitely a good case to reduce further enrollment . ( ie limit to 160 patients )
That would be a huge break for the Co ...and they definitely need one.

ICU is by far the riskiest and 1 of the smaller positions in my portfolio ...
JMO