A good example of a prior was most people on this board used to believe FGEN was a credible company. No matter what contradictory things the company said that made no sense at all to an objective observer and you told them they didn't make any sense most people wouldn't believe you until the dead end.
Addendum—I edited my post before you replied, replacing the word, "main" with the phrase, "most salient." Isaac's main point is the blame game you aptly debunked.
p.s. From reading your post one might think ADCs comprised the majority half of the drug/biotech industry!