Replies to post #443 on Fate Therapeutics Inc (FATE)

[NY1972]

FT836 = FT825 targeting MICA/B + ADR?

Recognition of Stress Molecules: ?d T cells recognize stress-induced molecules, like MICA/B and ULBP, that are commonly upregulated on tumor cells. This recognition is independent of the MHC system, which allows ?d T cells to identify and infiltrate tumor sites without requiring specific antigen presentation, as conventional T cells do.

[jondoeuk]

In the context of cancer, different tumour types can vary in their secretion of chemokines, and successful T- (or NK) cell trafficking depends on matching the chemokine with its appropriate chemokine receptor. Chemokines also recruit immunosuppressive cells into the TME.