Replies to post #437047 on Anavex Life Sciences Corp (AVXL)

[bas2020]

falconer, thanks for this interesting comparison...

A rat’s month is 2.78% of its entire life span. So, 2.78% of a human’s 80-year lifespan would be 2.224 years. Consequently, the rat’s final no-dosing month was equivalent to 2.224 years in an elderly human’s life. For the rats, in that final month, equivalent to 2.224 human years, no Alzheimer’s symptoms appeared. After dosing stopped, Anavex 3-71 continued to work, keeping the drug-free rats symptom-free for the equivalent of at least 2.224 human years.

Would the half-lives of 3-71 and its metabolite be the same in both mice and humans, or would they be "sped up" in mice because of the a higher metabolism?

Nonetheless, an amazing potentially prophylaxes result.

[rx7171]

I agree with your point but I would like to see 2 and 3 month non treatment data.
If as good that will be mind blowing.
I hope they extended the period unless ran out of rats to dissect.