Replies to post #425898 on Anavex Life Sciences Corp (AVXL)

[tschussmann1]

Interesting conjecture. In a discussion with Dr Alan Green, he stated that none of his APOE4 patients have so far progressed to dementia while on once weekly Rapamycin. Per a Georgejjl post, Rapamycin and A 2-73 have very similar binding sites (Sigma1 region). I believe Dr Green stated that about half his 1300 patients are APOE4. His practice started several years ago, but of course some of the 1300 have much less time duration. Dr Green does believe that Rapamycin on its own merits is strongly beneficial in the prevention of dementia. Might the MOA for both involve at least partial neuron "reset"? As you said, that would be rather significant...

[nidan7500]

We'll have to see how or if this develops. Of course, Anavex executives already know the answer, from closed-door murine (lab rodent) studies. This would be blarcamesine's yet unrevealed antiaging property. Might those be restricted only to aging neurons; or, for other body tissues, organs, and processes? Eventually, will everyone be taking a blarcamesine pill each day to maintain youthful health and function deep into life?

by falconer66a...

Great leadership thinking falconer66a, thank you. Now all we need to do is get a working AI model populated and structured around this clinical model(s) . Then we need to get Dr.M. and team to run/demo AI /[ FDA ]"prove by provision of objective evidence" that it is true and then the validation is complete.

BTW, this is an excellent example of "Systems Thinking". P. Senge, " The Fifth discipline". IMO, that is why we have CNS

Excellent stuff.

[bas2020]

A 'reset' is quite possible; however, I recall the Rett(?) trial where patients worsened during the drug "holiday", but resumed improvement once blarcamesine was restarted.

[frrol]

Some good stuff in this post. But it ends poorly. You're mistaken about what a biotech's management "knows". They don't 'secretly know' that an experimental drugs works. This is amateur biotech speculation that is unfortunately common in public message boards. As are false prophets. Folks have to be very careful about seeking confirmation from them about a golden-ticket stock they are blindly speculating in. Drugs are only proven therapeutic by controlled clinical trials. Not by lab research, and not nearly by a high school biology teacher with an undergrad bio degree and foolish (doubly so for anytime having any scientific training, and any common sense) hard faith in mouse models.

Management will eventually provide proper disclosure of our fairly robust AD trial's results. It will include helpful biomarker data that could be very encouraging. And we'll be getting TLR for the pediatric Rett trial. There are some other long-promised developments likely coming too. Investors are watching for these. Very exciting. There's a lot of research showing exogenously induced agonism of a MAM protein complex called S1 might be therapeutic, and broadly so. We're trying to prove that in humans with real disease using our experimental drug.

[scorman1]

The question? Does blarcamesine therapy persist, even after efficacious dosings have terminated?

OH, you mean just like the simufilam CMS completed trial that shows EXACTLY that, but the hypestyers here dismiss?
BTW, exactly how many "super responders" did we have in 2b/3 "met all endpoints" data....the lead pump cabal antagonists refuse to submit a number no matter how many times I query them....something to hide? is it 5 or 50 or 150??? a number please

[Schmiggins]

Well, how else do you explain baby-faced eighty year old Missling's hair?