Anavex Life Sciences Corp (AVXL)

[tschussmann1]

Interesting conjecture. In a discussion with Dr Alan Green, he stated that none of his APOE4 patients have so far progressed to dementia while on once weekly Rapamycin. Per a Georgejjl post, Rapamycin and A 2-73 have very similar binding sites (Sigma1 region). I believe Dr Green stated that about half his 1300 patients are APOE4. His practice started several years ago, but of course some of the 1300 have much less time duration. Dr Green does believe that Rapamycin on its own merits is strongly beneficial in the prevention of dementia. Might the MOA for both involve at least partial neuron "reset"? As you said, that would be rather significant...