Anavex Life Sciences Corp (AVXL)

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Does blarcamesine reset the functional age of neurons?

We had super responders to anavex 2-73. Wonder how they are doing?

Yes, how are they doing?

But here's a much bigger question, the answer to which could change health care and medical practice dramatically.

The question? Does blarcamesine therapy persist, even after efficacious dosings have terminated?

It's very possible that after blarcamesine has restored normalized cellular processes, such as calcium transport, protein folding, autophagy, and all the rest, they will all continue without persisting dosings of blarcamesine. Understand, twenty-three-year-olds don't often suffer from Alzheimer's. Except in rare genetic cases, it's a geriatric onset disease, appearing in middle age or later. In people with the disease, by late middle age, neuron cell physiology has deteriorated and Alzheimer's symptoms begin to appear. Neurons are aging and "wearing out." By its activation of the sigma-1 receptor protein, blarcamesine puts things back the way they were in more youthful years. Neurons function normally, with consequent good health.

Now, here's the conjecture. If it takes several decades, starting in middle age, for Alzheimer's symptoms to appear, for the neuron to "wear down," might it be possible that once blarcamesine has done its work, there would then be a restart to normal age-related cellular decline? After a sufficient period of normalized function induced by blarcamesine, have the diseased neurons been restored to their more youthful status? For a 70-year-old woman with Alzheimer's, might a course of blarcamesine therapy restore her nerves to the status she had when she was, say, 40, with several ensuing decades of normal mental health?

We'll have to see how or if this develops. Of course, Anavex executives already know the answer, from closed-door murine (lab rodent) studies. This would be blarcamesine's yet unrevealed antiaging property. Might those be restricted only to aging neurons; or, for other body tissues, organs, and processes? Eventually, will everyone be taking a blarcamesine pill each day to maintain youthful health and function deep into life?