Hitting three targets may not be the best way to go, due to the kinds of safety/tolerability issues described in #msg-172222042.
It might be okay for weight loss because many patients will only use the medications for a modest time period then come off once they have lost a target amount of weight. for NASH presumably the duration is much longer. then again the motivation to stay on to prevent serious liver conditions may be high, and I don't know if titration combined with antiemetics etc can address a good chunk of the GI tox. Nevertheless the theme of late has been glucagon agonism is bad until this latest data from LLY
News 
Market Data 
Discover 
