It really has nothing to do with brilliant minds. It's up to what the FDA realistically expects. Placebo controls are more reliable than everyone in a trial knowing they are taking a drug (OLE), especially in a population that is so mild that roughly 20% are misdiagnosed. I know at least one BP that assumes that rate in one of their early AD trials. Those are just the realities and why it takes so long for approvals whether right or wrong. I promise you that there won't be a 47% "super responder" group in the current trial but lets hope for something as close as possible. It will be 2 years before we know however. I'm thankful SAVA hit the ground running and are running concurrent trials.
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