The low float is very important here, the idea that someone can wait until after positive trial results and then find a market where existing shareholders that have carried the risk over time would be willing to unload their shares at merely 80% above the current price, is not remotely realistic, IMHO...
I fully expect a sharp correction to market value, a massive gap up, there are no free lunches... That is not to say that maybe someone couldn't buy shares at $200 and then see them hit $500 within a short time frame, but the upside leverage will be greatly diminished...
If you want to play this one, you should already be in or get in ASAP...
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