>>> FVIII is an unusual place for an anticoagulant to intervene in the cascade. <<<
I'm curious about why you think so. Given the FVIII / hemophilia connection , it strikes me as an obvious place to intervene.
I haven't followed this area , but it would seem logical to have separate drugs that can intervene in all three pathways - intrinsic , extrinsic , and common - for maximum flexibility , no ?