One of the basic chemical things few people catch on to, is freshman inorganic chemistry of iron. It is a free radical initiator known as a Fenton's reagent.
Leaky BBB-Blood Brain Barrier, and capillary leak syndrome can leak iron containing hemoglobin into parts of the body in a way that starts run away inflammation.
Ever seen H2O2 hydrogen peroxide foam and bubble on contact with blood from a wound?
That is the iron reacting with the iron in the blood to form the most potent free radical known to man, Super Oxide Anion, which is a tri-radical O2 + an extra unpaired electron O2(-). It is what started the fire and killed 3 astronauts in Apollo one on the Launch pad, and it is why Hospitals stopped using pure O2 on lung patients with Lung Cancer in the early 1970s..
The iron in our blood is great disinfectant when we are cut and bleed...
More on that story later....