Replies to post #413 on Idenix Pharmaceuticals (IDIX)

[gofishmarko]

>> i am concerned that there had been an indication where this agent might cause chrons disease. Gi-5005 is modified through dna to produce a substance found in the hepatitis c virus. <<

I'm not sure I understand the question. Are you concerned about a connection between Crohn's disease and HCV ? That's not the reason for the exclusion criteria in this trial. Crohn's patients , probably due to leaky guts , develop immune responses , including antibodies , to many gut flora including yeast. The concern is , IMO anyway , that the yeast vector would aggravate Crohn's by further stimulating the anti-yeast response.