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tootalljones

09/27/21 2:53 PM

#2403 RE: runncoach #2402

do your own dd, you are smart....my take is that there is a placebo, but it goes down and down over time, and eventually must be eliminmated and eradicted and squealched over time, which should be conceptually obvious, but we are dealing with mind body dualism.

12 months? I will take the other side of that bet and give major odds, and in any event, the "placebo effect,: a much promoted statistican thing, cannot approximate our recent 12 month results.

people making this argument, I will give 5 to 1 no 20 to 1 no 50 to 1. ...it is not like taking the cowgirls tonight vs. the birds....

this is about being irrationally skeptical. not good
time will show this.
it has done so with many now famous drugs
we will probably be bought here, soon enough

blah
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aCryptoKing

09/27/21 3:15 PM

#2409 RE: runncoach #2402


No I can't. I wrote that in a hurry. Meant that it's generally believed the placebo affect "normalizes" after a period. Not that it's absent. And in some cases with Schizophrenia, for example, it has been shown to increase.

I'm referencing the study design where there IS NO placebo in these open label trials. Like I said EARLIER: It is just a step!

Then we take THE NEXT. Where there will be a placebo & we'll see how she does.

Can anyone show me a drug that performed better to this point without any adverse effects?

138 or so drugs Big Pharma pipelined for AH's & I don't recall seeing ANYTHING better to this 12mo P2T timeframe. Correct me if I'm wrong.
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FooBarAndGrill

09/27/21 4:45 PM

#2419 RE: runncoach #2402

I think of placebo effect as a tapering half-life. Maybe it never really ends but I'm quite sure that by 12 months most of the buzz is done.