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DewDiligence

05/29/21 12:27 PM

#238193 RE: Doc328 #238191

The points about progress for other [AD] drugs is interesting but I partially disagree.

This is the crux of the matter (IMO), as discussed in #msg-164107790.
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swampboots

05/29/21 3:36 PM

#238198 RE: Doc328 #238191

As an non-medical observer the editorial was unprecedented, and gave me no assurance the drug had proven to be even mediocre. Further, I would
in my opinion only, advance the notion, that if I was credentialed to see such patients with Alzheimer's, knowledge of an FDA approved "something" drug would finally stop dead in its tracks, the dread I would have explaining to the patient and family that I could not lift a finger to slow the inevitable catastrophic circumstance.. Free of such a burden, I may be less susceptible to forming a bias unfavorable to the discussed drug approval by the FDA, which finally authorizes me to claim to the patient and family I have some sort of remedy to slow the impending rapid brain functioning deterioration.
I would be eager to hear a debate regarding this affair and proposals to remedy the merits of this disputable drug, by other "worthy" leading edge drug trial scholars, published in Nature or similar esteemed publications.
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Biowatch

05/29/21 3:54 PM

#238200 RE: Doc328 #238191

A problem with a marginal benefit for a drug that patients and their families desperately want is self-delusion.

We all see what we want to see, and we really want to see some treatment for a debilitating disease that robs people of their minds and their ability to recognize their loved ones or remember recent events.

Unfortunately it is the perfect market for snake oil salesmen, particularly given that close family members would like to reverse the march of time.

I’m not saying that this is snake oil, just that there could be strong consumer pressure to approve it, especially if they start an ad campaign.
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If you remember, there was a strong consumer push to have bone marrow transplants to treat breast cancer patients, which was allowed to go forward, but in the end clinical data showed that it provided no survival benefit, despite patients undergoing a very harsh and unpleasant regime.

False Hope: Bone Marrow Transplantation for Breast Cancer
https://www.nejm.org/doi/full/10.1056/NEJMbkrev58584