Sorry , I didnt see this new moderates patients protocol.
You were right that what they decided for the first time , first 700 mg SC then 3 SC 350 mg . This makes me nervous , I must say.. but hopefully they have a reason for it.
I was talking about the trial for critical patients. I thought Recknor suggested that protocol in a conference call. The fact that the moderate trial has that for protocol is just a coincidence.
I think 700mg for all doses is better. Leronlimab is 100% safe when a patient takes a 700mg weekly dose for years so there is no safety concern. In the CD12, there would have still been about 80% left of a 700mg dose on day 17 and 40% left on day 27 with a 10 day half-life. So if a 3rd and 4th dose are needed, then the 700mg dose is probably also needed.