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DonDonDonDon

05/25/21 3:11 PM

#167744 RE: misiu143 #167738

Sorry , I didnt see this new moderates patients protocol.

You were right that what they decided for the first time ,
first 700 mg SC then 3 SC 350 mg .
This makes me nervous , I must say.. but hopefully they have a reason for it.


I was talking about the trial for critical patients. I thought Recknor suggested that protocol in a conference call. The fact that the moderate trial has that for protocol is just a coincidence.

I think 700mg for all doses is better. Leronlimab is 100% safe when a patient takes a 700mg weekly dose for years so there is no safety concern. In the CD12, there would have still been about 80% left of a 700mg dose on day 17 and 40% left on day 27 with a 10 day half-life. So if a 3rd and 4th dose are needed, then the 700mg dose is probably also needed.