Please explain your statement that the "endpoint formula" has changed.
The endpoints of the trial did not change. For those who have not followed the leronlimab trials (available here,https://www.clinicaltrials.gov/ct2/show/NCT04343651?term=leronlimab&draw=2&rank=4 with history of changes available at the bottom of each trial's page), I have copied the history of changes (side-by-side), with additions in green and deletions in red.
Careful observers will notice two things. One, that I only included the primary and first 5 secondary outcome criteria. Two, that there are no changes.
I am attempting to spare our careful readers having to looks at three pages of UNCHANGED clinical trial endpoints
The statement made was that
endpoint formula here has been changed ex-post
I understand that mathematics is a field of constant discovery, but I doubt that the basics of statistical analysis and calculation of endpoint significance has changed mid-trial.
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