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CTMedic

01/16/21 10:20 AM

#140815 RE: Irishvox #140812

Irishvox,

There is the ability to label leronlimab, but I am quite convinced that this is not the case in CD10 or CD12. The results of the trials are what counts. Labeling would be very appropriate if trying to determine MOA, duration of receptor occupancy, etc.

In the case of the trials, the clinical results are the metrics by which leronlimab will be judged.

I listened to the Tedx Traverse city talk, but not recently.

I believe Dr. Patterson stated that, either in the Ted talk and/or one of the Youtube interviews, that they were seeing "interesting results" after Leronlimab administration.

I took this to mean that they were seeing marked immune restoration (CD4 and CD8 levels and ratio), which was indicative of which patients received Leronlimab.
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FooBarAndGrill

01/16/21 10:33 AM

#140819 RE: Irishvox #140812

I don't see any way to add a florescent marker to any molecule without altering the chemical properties of the molecule.

A hydrogen isotope could be used during manufacture without altering the chemical properties. And the isotope is easily detectable with the proper tools.
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theswordman

01/16/21 1:46 PM

#140876 RE: Irishvox #140812

FLOUROCHROME marker--If you saw/listened to the Beckman Coulter/Dr Patterson webcast --he talks about the marker in LL--how they measure