Replies to post #21525 on Revive Therapeutics Ltd (RVVTF)

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RVVTF Bucillamine:

Bucillamine Inhibits UVB-induced MAPK Activation and Apoptosis in Human HaCaT Keratinocytes and SKH-1 Hairless Mouse Skin
Article

Feb 2020

Adil AnwarHiba AnwarTakeshi Yamauchi[...]

Mayumi Fujita

Ultraviolet B (UVB) radiation is known as a culprit in skin carcinogenesis. We have previously reported that bucillamine (N-[2-mercapto-2-methylpropionyl]-L-cysteine), a cysteine derivative with anti-oxidant and anti-inflammatory capacity, protects against UVB-induced p53 activation and inflammatory responses in mouse skin. Since MAPK signaling pathways regulate