Replies to post #19950 on Mymetics Corp (MYMX)

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HIV-1 gp41-specific monoclonal mucosal IgAs derived from ...
www.nature.com/articles/mi200989
Jul 08, 2009 · Gp41 constructs 32 with sequence from the HXB2 HIV-1 clone were kindly provided by Mymetics (Nyon, Switzerland and Protein X’pert, Grenoble, France) and comprise the following: (1) trimeric gp41 ...
https://www.nature.com/articles/mi200989
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The present invention deals with a modified polypeptide comprising three contiguous segments N, L and C represented by the formula N-L-C and comprising: a N-helix region of gp41 (N), a C-helix region of gp41 (C), and a connecting loop comprising a synthetic linker (L) between the N and C-helices, the linker replacing amino acids 593-617 of gp41, the numbering scheme being based upon the prototypic isolate HIV-1 HxB2 Clade B strain, said polypeptide comprising the calveolin-1 neutralizing and 98.6 D epitopes, but not 2F5 and 4E10 epitopes, not the fusion peptide, the polypeptide having a minimal immunogenic cross-reactivity with human interleukin 2 (IL2).
Inventors:
Fleury, Sylvain (Ch Bottens, CH)
Mouz, Nicolas (Saint Paul de Varces, FR)
Roger, Marie-gaelle (Grenoble, FR)
http://www.freepatentsonline.com/8765137.html